In Exchange 2007 or 2010, we may use Transport Rules to disable internal OOF messages. For example:

Apply rule to messages

  from users that are ‘inside the organization’

              and sent to users that are ‘inside the organization’

                           and if the message type is ‘Automatic Reply’

                                        Delete the message without notifying anyone.

For more information on how to create a Transport Rule:

Create a Transport Rule

http://technet.microsoft.com/en-us/library/bb124737.aspx

 

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